GALR2 (I238) polyclonal Antibody | BS2797

GALR2 (I238) polyclonal Antibody | BS2797 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30 amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7 transmembrane family of G protein coupled receptors. GALR2 interacts with the N terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GALR2 (I238) pAb detects endogenous levels of GALR2 protein.

Molecular Weight: ~40.0 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Galanin receptor type 2; GAL2-R; GALR-2; GALR2; GALNR2

Immunogen: Synthetic peptide, corresponding to amino acids 211-260 of Human GALR2.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A