GAP43 polyclonal Antibody | BS90559

GAP43 polyclonal Antibody | BS90559 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, mouse, rat

Application: WB ICC IHC FC

Application Range: WB:1:1,000 ICC:1:200 IHC:1:200 FC:1:100-1:200

Background: GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity. The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. As a consequence, in the cerebellum, the neuronal precursor pool fails to expand normally and the cerebellum is significantly smaller.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: GAP43 polyclonal Antibody detects endogenous levels of GAP43 protein.

Molecular Weight: 43 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NEUM, Gap43, Axonal membrane protein GAP 43, Axonal membrane protein GAP-43, B 50, Calmodulin binding protein P 57, F1, GAP 43, GAP43, Growth Associated Protein 43, Growth-associated protein 43, Nerve Growth Related Peptide, Nerve growth related peptide GAP43, NEUM, Neural phosphoprotein B 50, Neural phosphoprotein B-50, Neuromodulin, Neuron growth associated protein 43, PP46, Protein F1, QtrA-11580, QtrA-13071,

Immunogen: peptide

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified

Pathway: