GARS Antibody [AMM22207G]

GARS Antibody [AMM22207G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This GARS antibody is generated from a mouse immunized with a recombinant protein between 35-305 amino acids from human GARS.

Cellular Localisation: Cytoplasm. Cell projection, axon. Secreted {ECO:0000250|UniProtKB:Q9CZD3}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:Q9CZD3}. Note=In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus (PubMed:17035524) Secreted by motor neuron, possibly through the exosome pathway (By similarity) . {ECO:0000250|UniProtKB:Q9CZD3, ECO:0000269|PubMed:17035524} [Isoform 2]: Cytoplasm. Cell projection, axon

Molecular Weight: 83166

Clone: Monoclonal

Gene Name: GARS1 (HGNC:4162)

Gene ID: 2617

Function: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:28675565, PubMed:24898252) . Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017) .

Summary: Tissue Location: Widely expressed, including in brain and spinal cord. [Isoform 1]: Expressed in brain, spinal cord, muscle, heart, spleen and liver.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, FC

Dilution: FC--1:25 WB--1:4000

Synonyms: Glycine--tRNA ligase, 6.1.1.14, Diadenosine tetraphosphate synthetase, AP-4-A synthetase, Glycyl-tRNA synthetase, GlyRS, GARS