GAS2L2 Antibody (C-term) [APR16076G]

GAS2L2 Antibody (C-term) [APR16076G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GAS2L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 763-791 amino acids from the C-terminal region of human GAS2L2.

Cellular Localisation: Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250|UniProtKB:Q5SSG4}. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with ADORA2A at neuronal processes (By similarity) . Colocalizes with and tracks the tips of microtubule plus ends (PubMed:24706950) {ECO:0000250|UniProtKB:D3ZUE1, ECO:0000269|PubMed:24706950}

Molecular Weight: 96520

Clone: Polyclonal

Gene Name: GAS2L2

Gene ID: 246176

Function: Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950) . Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950) . Enhances ADORA2- mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity) . Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704) .

Summary: Tissue Location: Expressed in bronchial and nasal epithelial cells (at protein level) (PubMed:30665704) . Expressed in brain, kidney, lung, testis, fallopian tubes, and skeletal muscle (PubMed:12584248, PubMed:30665704) . Expressed at low levels in stomach and colon (PubMed:30665704) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: GAS2-like protein 2, GAS2-related protein on chromosome 17, Growth arrest-specific protein 2-like 2, GAS2L2, GAR17