GAS41 (YEATS4/NuBI-1) Antibody (N-term F2) [APR31757G]

GAS41 (YEATS4/NuBI-1) Antibody (N-term F2) [APR31757G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GAS41 (YEATS4/NuBI-1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human NuBI-1.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00376, ECO:0000269|PubMed:10913114, ECO:0000269|PubMed:18445686}

Molecular Weight: 26499

Clone: Polyclonal

Gene Name: YEATS4 (HGNC:24859)

Gene ID: 8089

Function: Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12963728, PubMed:14966270) . Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed:29437725, PubMed:30071723, PubMed:29900004) . Also able to recognize and bind crotonylated histone H3 (PubMed:30071723) . May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ) ; additional evidences are however required to confirm this result in vivo (PubMed:29463709) . Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed:29437725) . H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity) .

Summary: Tissue Location: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: YEATS domain-containing protein 4, Glioma-amplified sequence 41, Gas41, NuMA-binding protein 1, NuBI-1, NuBI1, YEATS4, GAS41