GATA6 Antibody (C-term) [APR04744G]

GATA6 Antibody (C-term) [APR04744G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GATA6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 551-585 amino acids from the C-terminal region of human GATA6.

Cellular Localisation: Nucleus

Molecular Weight: 60033

Clone: Polyclonal

Gene Name: GATA6

Gene ID: 2627

Function: Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924) . Regulates SEMA3C and PLXNA2 (PubMed:19666519) . Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713) . May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778) . Involved in bone morphogenetic protein (BMP) -mediated cardiac-specific gene expression (By similarity) . Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity) . In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti- inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341) .

Summary: Tissue Location: Expressed in heart, gut and gut-derived tissues. Expressed in skin upper pilosebaceous unit. Expression is decreased or lost in acne lesions (PubMed:33082341) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Transcription factor GATA-6, GATA-binding factor 6, GATA6