GATSL1 Antibody (N-term) [APR31776G]

GATSL1 Antibody (N-term) [APR31776G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GATSL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-51 amino acids from the N-terminal region of human GATSL2.

Cellular Localisation: Cytoplasm, cytosol.

Molecular Weight: 36056

Clone: Polyclonal

Gene Name: CASTOR2 {ECO:0000303|PubMed:26972053, ECO:0000312|HGNC:HGNC:37073}

Gene ID: 729438

Function: Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2- containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

Summary: Tissue Location: Widely expressed..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P-Leica, WB

Dilution: IHC-P-Leica--1:250 WB--1:1000

Synonyms: GATS-like protein 1, GATSL1