GBA2 Antibody (Center) [APR16086G]

GBA2 Antibody (Center) [APR16086G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This GBA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 593-623 amino acids from the Central region of human GBA2.

Cellular Localisation: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q69ZF3}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q69ZF3}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q69ZF3}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q69ZF3}. Note=Localization to the plasma membrane and alternative topologies have also been reported

Molecular Weight: 104649

Clone: Polyclonal

Gene Name: GBA2 (HGNC:18986)

Gene ID: 57704

Function: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide (PubMed:17105727, PubMed:30308956) . Glucosylceramides are membrane glycosphingolipids that have a wide intracellular distribution (By similarity) . They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity) . Also involved in the transglucosylation of cholesterol, transferring glucose from glucosylceramides, thereby modifying its water solubility and biological properties (By similarity) . Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl- beta-D-glucoside to ceramide (By similarity) . Finally, may also play a role in the metabolism of bile acids (PubMed:11489889, PubMed:9111029, PubMed:17080196) . It is able to hydrolyze bile acid 3-O-glucosides but also to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:11489889, PubMed:9111029, PubMed:17080196) . However, the relevance of both activities is unclear in vivo (By similarity) .

Summary: Tissue Location: Widely expressed (PubMed:11489889) . Mainly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower levels in liver, spleen, small intestine and lung (PubMed:11489889) . Detectable in colon, thymus and peripheral blood leukocytes (PubMed:11489889) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Non-lysosomal glucosylceramidase, NLGase, 3.2.1.45, Beta-glucocerebrosidase 2, Beta-glucosidase 2, Glucosylceramidase 2, GBA2, KIAA1605