GBP5 Antibody (N-term) [APR31516G]

GBP5 Antibody (N-term) [APR31516G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GBP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of human GBP5.

Cellular Localisation: Cytoplasm. Golgi apparatus membrane; Lipid- anchor

Molecular Weight: 66617

Clone: Polyclonal

Gene Name: GBP5

Gene ID: 115362

Function: As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501) . Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847) .

Summary: Tissue Location: Expressed in peripheral blood monocytes (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Guanylate-binding protein 5, GBP-TA antigen, GTP-binding protein 5, GBP-5, Guanine nucleotide-binding protein 5, GBP5