GCGR Antibody (Center) [AMM04746G]

GCGR Antibody (Center) [AMM04746G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This GCGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human FOXC1.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Note=Is rapidly internalized after ligand-binding

Molecular Weight: 54009

Clone: Polyclonal

Gene Name: GCGR

Gene ID: 2642

Function: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000 WB--1:1000

Synonyms: Glucagon receptor, GL-R, GCGR