GFI1 Polyclonal Antibody | BS65757

GFI1 Polyclonal Antibody | BS65757 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Horse,Rabbit,Sheep,Xenopus laevis

Application: WB,

Application Range: WB=1:500-2000

Background: Growth factor independent 1 (Gfi-1) is a transcriptional repressor that specifically binds to the DNA consensus sequence TAAATCAC (A/T) GCA. The carboxy-terminus of Gfi-1 contains six C2H2-type zinc finger motifs, and zinc fingers 3, 4 and 5 are required for the binding of Gfi-1 to its DNA binding site. Gfi-1 also contains a 20 amino acid SNAG domain which mediates transcriptional repression. It represses Bax at the mRNA and protein levels, resulting in the inhibition of cell death. Gfi1 is expressed outside the lymphoid system in granulocytes and activated macrophages. Gfi-1B, a related protein, is a transcriptional repressor primarily expressed in bone marrow and spleen. Gfi-1B is a direct repressor of the p21 promoter and the Socs 1 and 3 promoters. The genes encoding human Gfi-1 and Gfi-1B map to chromosome 1p22 and 9q34.3, respectively.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GFI1 Polyclonal Antibody detects endogenous levels of GFI1 protein.

Molecular Weight: 49 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: GFI 1; GFI1; GFI-1; GFI1_HUMAN; Growth factor independence 1; growth factor independent 1; Growth factor independent protein 1; SCN2; Zinc finger protein 163; Zinc finger protein Gfi 1; Zinc finger protein Gfi-1; Zinc finger protein Gfi1; ZNF 163; ZNF163.聽

Immunogen: KLH conjugated synthetic peptide derived from human GFI1/ZNF163:301-400/422

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: Nuclear Receptor Signaling,Nuclear Receptor Signaling,