GFR alpha 1 Antibody | 1133

GFR alpha 1 Antibody | 1133 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: GFR alpha 1 antibody was raised against a 14 amino acid peptide near the center of human GFR alpha 1.
The immunogen is located within amino acids 360 - 410 of GFR alpha 1.

Research Area: Growth Factors, Neuroscience

Tested Application: E, WB, IHC-P, IF

Application: GFR alpha 1 antibody can be used for detection of GFR alpha 1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 1 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

Positive Control 1: Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 2: Cat. No. 1304 - Human Liver Tissue Lysate

Positive Control 3: Cat. No. 1305 - Human Kidney Tissue Lysate

Positive Control 4: Cat. No. 1306 - Human Spleen Tissue Lysate

Positive Control 5: Cat. No. 10-301 - Human Brain Tissue Slide

Positive Control 6: N/A

Molecular Weight: 51 kDa

Validation: N/A

Isoform: N/A

Purification: GFR alpha 1 Antibody is Antibody is DEAE purified.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: GFR alpha 1 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: GFR alpha 1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: GFR alpha 1 Antibody: GDNFR, RET1L, RETL1, TRNR1, GDNFRA, GFR-ALPHA-1, GDNF family receptor alpha-1, RET ligand 1, GDNF receptor alpha-1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: GFR alpha 1 Antibody: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα-1 recently. GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.