GIGYF2 Antibody (Center) [APR12024G]

GIGYF2 Antibody (Center) [APR12024G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GIGYF2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 835-869 amino acids from the Central region of human GIGYF2.

Cellular Localisation: N/A

Molecular Weight: 150070

Clone: Polyclonal

Gene Name: GIGYF2 {ECO:0000303|PubMed:12771153, ECO:0000312|HGNC:HGNC:11960}

Gene ID: 26058

Function: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631) . In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631) . Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631) . May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: PERQ amino acid-rich with GYF domain-containing protein 2, GRB10-interacting GYF protein 2, Trinucleotide repeat-containing gene 15 protein, GIGYF2, KIAA0642, PERQ2, TNRC15