GLMN Antibody (C-term) [APR03649G]

GLMN Antibody (C-term) [APR03649G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GLMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-525 amino acids from the C-terminal region of human GLMN.

Cellular Localisation: N/A

Molecular Weight: 68208

Clone: Polyclonal

Gene Name: GLMN

Gene ID: 11146

Function: [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924) . Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924) . Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651) . Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity) . Essential for normal development of the vasculature (PubMed:11845407) . Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281) .

Summary: Tissue Location: Ubiquitous..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Glomulin, FK506-binding protein-associated protein, FAP, FKBP-associated protein, GLMN, FAP48, FAP68, VMGLOM