GLUL polyclonal Antibody | BZ00935

GLUL polyclonal Antibody | BZ00935 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IP FC

Application Range: WB: 1:500-1:2000 IHC: 1:50-1:200 IP/FC: 1:50

Background: Glutamine synthetase (GI Syn) forms a homooctamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Glutamine Synthetase Antibody detects endogenous levels of total Glutamine Synthetase.

Molecular Weight: ~ 49 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Glutamine synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase; GLNS; Gl Syn

Immunogen: A synthesized peptide derived from human Glutamine Synthetase.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: