GMF-beta, human recombinant | 4880

Glia Maturation Factor-Beta (GMF-Beta) is a 17 kDa protein nerve growth factor identified as a growth and differentiation factor in the vertebrate brain.Glia Maturation Factor-Beta stimulates differentiation of normal neurons as well as glial cells. GMFB inhibits the proliferation of the N-18 neuroblastoma line and the C6 glioma line while promoting their phenotypic expression. GMF-beta enhances the phenotypic expression of glia & neurons thus inhibits the proliferation of their respective tumors when added to cell culture. Cell- surface GMF-Beta acts on the target cells at close range when cells are in direct contact. GMF-Beta is produced by thymic epithelial cells and plays an important role in T cell development in favor of CD4+ T cells. GMF-Beta is a brain-specific protein which belongs to the actin-binding proteins (ADF) family. GMF-beta appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the progression of certain auto-immune diseases, possibly through its ability to induce the production and secretion of various pro-inflammatory cytokines.

4880 | GMF-beta human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Glia maturation factor beta, GMFB, GMF-B, GMF-beta, GMF

Alternates names: Apolipoprotein CII, apolipoprotein, apolipoproteins

Taglines: A growth and differentiation factor in the vertebrate brain

NCBI Gene ID #: 344

NCBI Gene Symbol: APOC2

Gene Source: Human

Accession #: P02655

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: 98%

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 8.8 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized after dialysis against 20 mM PBS pH 7.4 and 130 mM NaCl.

Reconstitution Instructions: Reconstitute in 50 ul of ddHO. Additional dilutions can be prepared in 10 mM NH4HCO3 , pH 7.4.

Amino acid sequence: N/A