GMPS polyclonal Antibody | BS8290

GMPS polyclonal Antibody | BS8290 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Purines are critical for energy metabolism, cell signaling and cell reproduction and also function as precursors for coenzymes, energy transfer molecules, regulatory factors and proteins involved in RNA and DNA synthesis. GMPS (guanine monphosphate synthetase), also known as GMP synthetase, is a 693 amino acid cytoplasmic protein that is involved in purine biosynthesis. Existing as a homodimer, GMPS catalyzes the last step in the GMP synthesis pathway, namely the ATP-dependent amination of XMP to GMP. GMPS contains one GMP-binding domain and one glutamine amidotransferase type-1 domain through which it conveys its catalytic activity. Chromosomal translocations involving the gene encoding GMPS are associated with acute myeloid leukemias, suggesting a possible role for GMPS in carcinogenesis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GMPS polyclonal Antibody detects endogenous levels of GMPS protein.

Molecular Weight: ~ 77 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: GMP synthase [glutamine-hydrolyzing]; GMP synthetase; Glutamine amidotransferase; GMPS

Immunogen: Recombinant full length Human GMPS.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: