GNA11 polyclonal Antibody | BS7429

GNA11 polyclonal Antibody | BS7429 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα (s), Gα (i/o), Gα (q) and Gα (12), based on structural and functional similarities (1,2) . Phosphorylation of Tyr356 of Gα (q) /Gα (11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GNA11 polyclonal Antibody detects endogenous levels of GNA11 protein.

Molecular Weight: ~42 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: G alpha-11; G-protein subunit alpha-11; GA11; GNA11; GNA11_HUMAN; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) ; Guanine nucleotide-binding protein G (y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11; guanine nucleotide-binding protein, alpha 11; guanine nucleotide-binding protein, Gq class, GNA11;

Immunogen: Recombinant full length Human GNA11.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: