GNAS Antibody (N-Term) [AMM04827G]

GNAS Antibody (N-Term) [AMM04827G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This GNAS antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 51-83 amino acids from human GNAS.

Cellular Localisation: Cell membrane {ECO:0000250|UniProtKB:P63094}; Lipid-anchor {ECO:0000250|UniProtKB:P63094}

Molecular Weight: 45665

Clone: Polyclonal

Gene Name: GNAS

Gene ID: 2778

Function: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs) (PubMed:17110384) . Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665) . GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135) . Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:8000

Synonyms: Guanine nucleotide-binding protein G (s) subunit alpha isoforms short, Adenylate cyclase-stimulating G alpha protein, GNAS, GNAS1, GSP