GNF-2 | 2470

An allosteric, non-ATP-competitive inhibitor of Bcr-Abl tyrosine kinase (IC₅₀ = 267 nM). GNF-2 inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells.

GNF-2 is an allosteric, non-ATP-competitive inhibitor of Bcr-Abl tyrosine kinase (IC₅₀ = 267 nM). GNF-2 inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells.

2470 | GNF-2 DataSheet

Alternate Name/Synonyms: 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

Appearance: White solid

Formulation: N/A

CAS Number: 778270-11-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₃F₃N₄O₂

Molecular Weight: 374.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml) or EtOH (>15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An allosteric Bcr-Abl tyrosine kinase inhibitor

MDL Number: MFCD09265253

PubChem CID: 5311510

SMILES: C1=CC(=CC(=C1)C(=O)N)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F

InChi: InChI=1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)

InChi Key: WEVYNIUIFUYDGI-UHFFFAOYSA-N