GNF-7 | B1139

GNF-7 is a multi-targeted kinase inhibitor that inhibits activated CDC42 kinase 1 (ACK1) and germinal center kinase (GCK) inducing cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. It also displays significant in vivo efficacy against T315l-Bcr-Abl without notable toxicity in a bioluminescent xenograft mouse model using transformed T315l-Bcr-Abl-Ba/F3 cell line that has a stable luciferase expression.

GNF-7 is a multi-targeted kinase inhibitor that inhibits activated CDC42 kinase 1 (ACK1) and germinal center kinase (GCK) inducing cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. It also displays significant in vivo efficacy against T315l-Bcr-Abl without notable toxicity in a bioluminescent xenograft mouse model using transformed T315l-Bcr-Abl-Ba/F3 cell line that has a stable luciferase expression.

B1139 | GNF-7 DataSheet

Alternate Name/Synonyms: N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide

Appearance: White Solid

Formulation: N/A

CAS Number: 839706-07-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₄F₃N₇O₂

Molecular Weight: 547.53

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A RAS signaling inhibitor

MDL Number: N/A

PubChem CID: 11478363

SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CN=C(C=C5)C

InChi: 1S/C28H24F3N7O2/c1-16-7-9-21(34-25(39)18-5-4-6-20(11-18)28(29,30)31)12-23(16)38-15-19-13-33-26(36-24(19)37(3)27(38)40)35-22-10-8-17(2)32-14-22/h4-14H,15H2,1-3H3,(H,34,39)(H,33,35,36)

InChi Key: SZNYUUZOQHNEKB-UHFFFAOYSA-N