Goat Anti-HPV11 HPV11 E6 Polyclonal Antibody | AB0107

Goat Anti-HPV11 HPV11 E6 IgG Polyclonal Antibody | AB0107 | Antibodies

Overview: Goat polyclonal antibody to HPV11 E6. E6 is one primary oncoprotein of high risk HPV types expressed early in the HPV life cycle. After the host cell is infected viral early promoter is activated and a polycistronic primary RNA containing all six early ORFs is transcribed. This polycistronic RNA then undergoes active RNA splicing to generate multiple isoforms of mRNAs. One of the spliced isoform RNAs, E6, serves as an E7 mRNA to translate E7 protein. HPV genome integrate into host genome by disruption of E2 ORF, preventing E2 repression on E6 and E7. Thus, viral genome integration into host DNA genome increases E6 expression. The E6 protein inactivates the tumour suppressor protein, p53 and promote cellular proliferation and the chance of malignancy.

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Other Names: N/A

Concentration: 3 mg/ml

Antibody Type: Primary

Target Type: Anti-HPV11 E6

Accession Number: N/A

Host Species: Goat

Immunogen Species: HPV11

Immunogen Type: Recombinant protein

Immunogen: Purified recombinant peptide derived from within residues 65 aa to N-terminal of HPV11 E6 produced in E. coli.

Isotype: IgG

Clonality: Polyclonal

Confirmed Reactive Species: Human papilloma viruses type 11

Specificity Detail: Detects HPV11 E6 recombinant fusion proteins MBP-E6 and GFP-E6 expressed in transfected mammalian cells.

Buffer: PBS, 20% glycerol and 0.05% sodium azide

Purification: Epitope affinity purified

Conjugation: Unconjugated

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Application: WB

Concentration/Dilution: WB:1:500-1:2,000

Storage: N/A

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