Goat Anti-Human 4-1BB receptor Antibody | 102-P100G

Goat Anti-Human 4-1BB receptor Antibody | 102-P100G | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Goat

Comment: N/A

Label: N/A

Clone / Antibody feature: Goat IgG

Subcategory: Polyclonal Antibody

Category: Antibody

Synonyms: TNFRSF9; ILA; 4-1BB; CD137; CDw137

Isotype: N/A

Application: ELISA, WB

Detection Range: N/A

Species Reactivity/Cross reactivity: Human

Antigen: highly pure (>98%) recombinant human 4-1BB Receptor

Description: 4-1BB (or human 4-1BBL receptor) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFR-SF9, CD137, and ILA. The 255 amino acid is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30 kDa glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% amino acid identity. 4-1BB is absent from naive T cells, but it is upregulated and continually expressed following T cell activation. The natural ligand, 4-1BBL, is a member of the TNF superfamily and is expressed on activated antigen presenting cells including dendritic cells, macrophages, and B cells. Crosslinking of 4-1BB by 4-1BBL or by agonistic antibodies transmits a potent co stimulatory signal that enhances the effect of other activating signals such as PHA or antiCD3 antibodies. 4-1BB signals through the TFAF2NIK pathway resulting in activation of NFκB and ultimately promoting proliferation and survival of T cells.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized from PBS

Storage Handling Stability: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

Reconstituation: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 3604