GP2 polyclonal Antibody | BS8169

GP2 polyclonal Antibody | BS8169 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein that is expressed in pancreatic secretory (zymogen) granules, and is cleaved then released into the pancreatic duct along with exocrine secretions. GP2 interacts with syncollin and to type 1 fimbria of bacteria, a bacterial adhesin that is commonly expressed by members of the Enterobacteriacae family. Containing an EGF-like domain and a ZP domain, GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases, and the GP2-dependent transcytotic pathway may provide a new target for the development of M-cell-targeted mucosal vaccines. GP2 exists as four alternatively spliced isoforms that are desginated isoform 1, isoform beta, isoform alpha and isoform 2.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GP2 polyclonal Antibody detects endogenous levels of GP2 protein.

Molecular Weight: ~ 59 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75; GP2

Immunogen: Recombinant full length Human GP2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: