GPR173 polyclonal Antibody | BS62424

GPR173 polyclonal Antibody | BS62424 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB

Application Range: WB: 1:500~1000

Background: Nectin-4/Poliovirus Receptor-Like 4 (PVRL4) is a type-I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and promotes cell-cell adhesion by serving as a major component of adherens junctions. The extracellular domain of Nectin-4, which contains an Ig variable-like domain (V) and two Ig constant-like domains (C), mediates binding to the measles virus and to neighboring cells through trans heterophilic interactions with Nectin-1. Unlike other nectin family members, which are widely expressed in adult tissues, Nectin-4 expression in humans is largely restricted to the placenta. Research studies have demostrated that Nectin-4 is overexpressed in a variety of human solid tumors of the pancreas, breast, lung, and ovary. Due to its restricted expression pattern in normal human tissues, Nectin-4 may serve as a novel diagnostic and therapeutic target for a variety of human tumors.

Storage & Stability: Store at 4°C short term. Aliquot and store at -21°C long term. Avoid freeze-thaw cycles.

Specificity: Nectin 4 polyclonal Antibody detects endogenous levels of Nectin 4 protein.

Molecular Weight: ~ 66 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Nectin-4; Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4; Poliovirus receptor-related protein 4; Processed poliovirus receptor-related protein 4; NECTIN4; LNIR; PRR4; PVRL4

Immunogen: Synthetic peptide, corresponding to Human Nectin 4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .

Pathway: