GPRASP1 Antibody | 7987

GPRASP1 Antibody | 7987 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: GPRASP1 antibody was raised against a 15 amino acid peptide near the amino terminus of human GPRASP1.
The immunogen is located within amino acids 260 - 310 of GPRASP1.

Research Area: Homeostasis

Tested Application: E, WB, IHC-P, IF

Application: GPRASP1 antibody can be used for detection of GPRASP1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: GPRASP1 antibody is human and mouse reactive. This antibody is predicted to not cross-react with GPRASP2.

Positive Control 1: Cat. No. 1288 - A20 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 153 kDa
Observed: 150 kDa

Validation: N/A

Isoform: N/A

Purification: GPRASP1 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: GPRASP1 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: GPRASP1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: G-protein coupled receptor-associated sorting protein 1, GASP, GASP-1, GASP1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The G protein-coupled receptor associated sorting protein 1 (GPRASP1) is a member of the GPRASP family and is thought to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors (1, 2) . GPRASP1 interacts with receptors such as the D2 dopamine receptor (DRD2) , delta opioid receptor (OPRD1) , beta-2 adrenergic receptor (ADRB2) , D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CNR1) and targets these proteins for degradation in lysosomes (2) . Recently, it has been shown that increased GPRASP1 levels may act as a potential biomarker for breast cancer (3) .