GPRC6A Antibody (Center) [APR12252G]

GPRC6A Antibody (Center) [APR12252G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GPRC6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-517 amino acids from the Central region of human GPRC6A.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 104753

Clone: Polyclonal

Gene Name: GPRC6A

Gene ID: 222545

Function: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca (2+) and Mg (2+) . Activated by extracellular calcium and osteocalcin. Seems to act through a G (q) /G (11) and G (i) -coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.

Summary: Tissue Location: Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes Expressed at intermediate level in liver, heart, kidney and spleen Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon Isoform 1 and isoform 2 are expressed in kidney at the same level Isoform 2 is expressed at lower level than isoform 1 in the other tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: G-protein coupled receptor family C group 6 member A, hGPRC6A, G-protein coupled receptor GPCR33, hGPCR33, GPRC6A