Granisetron Hydrochloride | B3205

Granisetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 3.9 nM) with antiemetic activity. It displays selectivity for 5-HT3 over 5-HT4 receptors (Ki = >1,000 nM). Formulations containing granisetron have been used in the prevention of nausea and vomiting associated with chemotherapy.

Granisetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 3.9 nM) with antiemetic activity. It displays selectivity for 5-HT3 over 5-HT4 receptors (Ki = >1,000 nM). Formulations containing granisetron have been used in the prevention of nausea and vomiting associated with chemotherapy.

B3205 | Granisetron Hydrochloride DataSheet

Alternate Name/Synonyms: BRL-43694,1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride,BRL 43694

Appearance: White to off-white solid

Formulation:

CAS Number: 107007-99-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₅ClN₄O

Molecular Weight: 348.87

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >10 mg/ml Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antagonist of the serotonin (5-HT) receptor subtype 5-HT3

MDL Number: MFCD01747034

PubChem CID: 6918003

SMILES: CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl

InChi: InChI=1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12?,13-,14+;

InChi Key: QYZRTBKYBJRGJB-PCMHIUKPSA-N