GRK2 (T23) polyclonal Antibody | BS1443

GRK2 (T23) polyclonal Antibody | BS1443 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs) . At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of β-adrenergic receptor kinase, GRK 2 (βARK, βARK1) and GRK 3 (βARK2) ; IT-11 (GRK 4) ; GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GRK2 (T23) polyclonal Antibody detects endogenous levels of GRK2 protein.

Molecular Weight: ~ 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Beta-adrenergic receptor kinase 1; Beta-ARK-1; β-ARK-1; ARK-β1; G-protein coupled receptor kinase 2; ADRBK1; BARK; BARK1; GRK2; ARK β1; ARKβ1; β-ARK1

Immunogen: Synthetic peptide, corresponding to the N-terminal of Human GRK2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Translational Contral elF4 and p70 S6 Kinase,Insulin &Glucose Signaling,MTOR signaling,