GRK5 (Q382) polyclonal Antibody | BS1981

GRK5 (Q382) polyclonal Antibody | BS1981 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs) . At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of b-adrenergic receptor kinase: GRK 2 (bARK, bARK1) and GRK 3 (bARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GRK5 (Q382) polyclonal Antibody detects endogenous levels of GRK5 protein.

Molecular Weight: ~ 68 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5; GPRK5

Immunogen: Synthetic peptide, corresponding to amino acids 350-400 of Human GRK5.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Hypoxia Signaling,Wntβ catenin signaling，Contribution of ECM and Cytoskeletal Factors to EMT,Contribution of Soluble Factors to EMT,hippo Signaling,Adherens Junction signaling,