GRL-0617 | B3079

GRL-0617 is a potent inhibitor of the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro cleaves the viral polyproteins. GRL-0617 inhibits SARS-CoV and SARS-CoV-2 PLpro in vitro with IC₅₀ values of 0.6 μM and 2.4 μM respectively. GRL-0617 shows antiviral activity with EC₅₀ values of 14.5 μM and 27.6 μM in SARS-CoV and SARS-CoV-2 virus-infected Vero E6 cells.

GRL-0617 is a potent inhibitor of the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro cleaves the viral polyproteins. GRL-0617 inhibits SARS-CoV and SARS-CoV-2 PLpro in vitro with IC₅₀ values of 0.6 μM and 2.4 μM respectively. GRL-0617 shows antiviral activity with EC₅₀ values of 14.5 μM and 27.6 μM in SARS-CoV and SARS-CoV-2 virus-infected Vero E6 cells.

B3079 | GRL-0617 DataSheet

Alternate Name/Synonyms: 5-amino-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide; 5-azanyl-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide

Appearance: Off-white solid

Formulation:

CAS Number: 1093070-16-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₀H₂₀N₂O

Molecular Weight: 304.393

Cell-Permeable?: TRUE

Purity: ≥97%

Solubilities: ~30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent inhibitor of the papain-like protease (PLpro) from coronavirus

MDL Number:

PubChem CID: 24941262

SMILES: CC1=C(C=C(C=C1)N)C(=O)NC(C)C2=CC=CC3=CC=CC=C32

InChi: InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1

InChi Key: UVERBUNNCOKGNZ-CQSZACIVSA-N