GSDMA Antibody (N-term) [APR05359G]

GSDMA Antibody (N-term) [APR05359G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This GSDMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GSDMA.

Cellular Localisation: [Gasdermin-A]: Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6}

Molecular Weight: 49365

Clone: Polyclonal

Gene Name: GSDMA (HGNC:13311)

Gene ID: 284110

Function: [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death.

Summary: Tissue Location: Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium Down-regulateded in gastric cancer cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Gasdermin-A, Gasdermin-1, GSDMA, GSDM, GSDM1