GSK-106 hydrochloride | B1036

GSK-106 is a useful negative control for PAD4 inhibitors (GSK-121 and GSK-484). It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC₅₀s > 100 µM).

GSK-106 is a useful negative control for PAD4 inhibitors (GSK-121 and GSK-484). It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC₅₀s > 100 µM).

B1036 | GSK-106 hydrochloride DataSheet

Alternate Name/Synonyms: (3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzo[d]imidazol-6-yl)methanone hydrochloride

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1652591-82-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₈ClN₅O

Molecular Weight: 437.97

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~30 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A useful negative control for PAD4 inhibitors GSK-121 and GSK-484.

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(N1CC(N)CCC1)C2=CC=C3C(N(C)C(C(N4CC)=CC5=C4C=CC=C5)=N3)=C2.[H]Cl

InChi: InChI=1S/C24H27N5O.ClH/c1-3-29-20-9-5-4-7-16(20)13-22(29)23-26-19-11-10-17(14-21(19)27(23)2)24(30)28-12-6-8-18(25)15-28;/h4-5,7,9-11,13-14,18H,3,6,8,12,15,25H2,1-2H3;1H

InChi Key: VRPFLFUQMWOJAT-UHFFFAOYSA-N