GSK-3 Inhibitor, AR-A014418 | 1953

Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

GSK-3 Inhibitor, AR-A014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases.

1953 | GSK-3 Inhibitor, AR-A014418 DataSheet

Alternate Name/Synonyms: N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea

Appearance: Off-white solid

Formulation: N/A

CAS Number: 487021-52-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₂N₄O₄S

Molecular Weight: 308.31

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (30 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A selective GSK-3 inhibitor

MDL Number: MFCD08277040

PubChem CID: 448014

SMILES: COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]

InChi: InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12) 16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)

InChi Key: YAEMHJKFIIIULI-UHFFFAOYSA-N