GSK-3β Inhibitor, TWS119 | 1655

A potent inhibitor of GSK-3β (Glycogen synthase kinase-3β) (IC₅₀ = 30 nM). At 400 nM, TWS119 induces neurogenesis in murine embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.

GSK-3β Inhibitor, TWS119 is a potent inhibitor of GSK-3β (Glycogen synthase kinase-3β) (IC₅₀ = 30 nM).

1655 | GSK-3β Inhibitor, TWS119 DataSheet

Alternate Name/Synonyms: 3-[[6-(3-Aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol

Appearance: Slightly pink solid

Formulation: N/A

CAS Number: 601514-19-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₄N₄O₂

Molecular Weight: 318.33

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A GSK-3β inhibitor

MDL Number: MFCD09037535

PubChem CID: 9549289

SMILES: C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O

InChi: InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)

InChi Key: VPVLEBIVXZSOMQ-UHFFFAOYSA-N