GSK-690693 | 2272

An ATP-competitive pan-Akt kinase inhibitor. Inhibits Akt kinase isoforms 1, 2, 3 with IC₅₀ values of 2, 13, and 9 nM, respectively. Inhibited proliferation and induced apoptosis in a subset of tumor cells with potency consistent with intracellular inhibition of Akt kinase activity.

GSK-690693 is an ATP-competitive pan-Akt kinase inhibitor. Inhibits Akt kinase isoforms 1, 2, 3 with IC₅₀ values of 2, 13, and 9 nM, respectively

2272 | GSK-690693 DataSheet

Alternate Name/Synonyms: 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)­-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[­4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

Appearance: Yellow solid

Formulation: N/A

CAS Number: 937174-76-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₇N₇O₃

Molecular Weight: 425.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A pan-Akt kinase inhibitor

MDL Number: MFCD14105605

PubChem CID: 16725726

SMILES: CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N

InChi: InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1

InChi Key: KGPGFQWBCSZGEL-ZDUSSCGKSA-N