GSK-J1 sodium salt | 2260

A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at higher concentrations (30 μM), has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases.

GSK-J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM for human JMJD3 in vitro).

2260 | GSK-J1 sodium salt DataSheet

Alternate Name/Synonyms: 3-​((6-​(4,​5-​dihydro-​1H-​benzo[d]azepin-​3(2H)-​yl)-​2-​(pyridin-​2-​yl)pyrimidin-4-yl)amino)propanoate, monosodium salt

Appearance: Crystalline solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₂H₂₂N₅O₂ ∙ Na

Molecular Weight: 411.43

Cell-Permeable?: No

Purity: ≥95%

Solubilities: DMSO

Handling: Protect from light and mositure

Country of Origin: USA

Tag Line: A potent histone demethylase JMJD3/UTX inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: N/A

InChi: N/A

InChi Key: N/A