GSK-J2 (Sodium Salt) | B2813

GSK-J2 (sodium salt) is an isomer of GSK-J1. GSK-1 is a selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX, with an IC₅₀ of 60 nM for human JMJD3 in vitro. GSK-J2 poorly inhibits JMJD3 with an IC₅₀ > 100 μM in vitro. GSK-J2 serves as a negative control for in vitro studies with GSK-J1.

GSK-J2 (sodium salt) is an isomer of GSK-J1. GSK-1 is a selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX, with an IC₅₀ of 60 nM for human JMJD3 in vitro. GSK-J2 poorly inhibits JMJD3 with an IC₅₀ > 100 μM in vitro. GSK-J2 serves as a negative control for in vitro studies with GSK-J1.

B2813 | GSK-J2 (Sodium Salt) DataSheet

Alternate Name/Synonyms: 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt, 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid;sodium

Appearance: Crystalline solid

Formulation:

CAS Number: 2108665-15-0

Structure Available?: True

Peptide sequence:

Salt Form: True

Molecular Formula: C₂₂H₂₃N₅NaO₂

Molecular Weight: 411.43

Cell-Permeable?: False

Purity: ≥90%

Solubilities: Sparingly soluble in aqueous and organic solvents such as DMSO, ethanol and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A negative control for in vitro studies with GSK-J1

MDL Number:

PubChem CID: 137699749

SMILES: C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CN=CC=C4)NCCC(=O)O.[Na]

InChi: InChI=1S/C22H23N5O2.Na/c28-21(29)7-11-24-19-14-20(26-22(25-19)18-6-3-10-23-15-18)27-12-8-16-4-1-2-5-17(16)9-13-27;/h1-6,10,14-15H,7-9,11-13H2,(H,28,29)(H,24,25,26);

InChi Key: LFPRQFGWKMRKLV-UHFFFAOYSA-N