GSK-J4 (Free base) | 2762

GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.

GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.

2762 | GSK-J4 (Free base) DataSheet

Alternate Name/Synonyms: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester

Appearance: Yellow waxy solid

Formulation: N/A

CAS Number: 1373423-53-0

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₇N₅O₂

Molecular Weight: 417.5

Cell-Permeable?: Y

Purity: ≥99% by TLC

Solubilities: DMSO (~ 40 mg/ml) or EtOH (~ 40 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A histone demethylase JMJD3/UTX inhibitor

MDL Number: MFCD22683852

PubChem CID: 71729975

SMILES: CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4

InChi: InChI=1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)

InChi Key: WBKCKEHGXNWYMO-UHFFFAOYSA-N