GSK137647A | B1112

GSK137647A is a a selective agonist of FFA4 (GPR120) (pEC₅₀s = 6.3, 6.2, and 6.1 at human, mouse, and rat receptors, respectively). It is selective for GPR120 over a panel of 61 other targets, including other FFARs. Like the natural GPR120 ligand linoleic acid, GSK137647A dose-dependently stimulates insulin secretion by mouse insulinoma MIN6 cells under high glucose conditions. It also modestly stimulates the production of glucagon-like peptide-1 in taste bud cells and human intestinal NCI-H716 cells.

GSK137647A is a a selective agonist of FFA4 (GPR120) (pEC₅₀s = 6.3, 6.2, and 6.1 at human, mouse, and rat receptors, respectively). It is selective for GPR120 over a panel of 61 other targets, including other FFARs. Like the natural GPR120 ligand linoleic acid, GSK137647A dose-dependently stimulates insulin secretion by mouse insulinoma MIN6 cells under high glucose conditions. It also modestly stimulates the production of glucagon-like peptide-1 in taste bud cells and human intestinal NCI-H716 cells.

B1112 | GSK137647A DataSheet

Alternate Name/Synonyms: 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide

Appearance: White solid

Formulation: N/A

CAS Number: 349085-82-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₉NO₃S

Molecular Weight: 305.39

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective FFA4 (GPR120) agonist

MDL Number: MFCD02007969

PubChem CID: 743974

SMILES: CC1=CC(=C(C(=C1)C)NS(=O)(=O)C2=CC=C(C=C2)OC)C

InChi: InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3

InChi Key: FQUAFMNPXPXOJE-UHFFFAOYSA-N