GSK1904529A | 2286

A potent, selective, reversible and ATP-competitive inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) and Insulin Receptor (IR) with IC₅₀s of 27 and 25 nM, respectively.

GSK1904529A is a potent, selective, reversible and ATP-competitive inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) and Insulin Receptor (IR) with IC₅₀s of 27 and 25 nM, respectively.

2286 | GSK1904529A DataSheet

Alternate Name/Synonyms: N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)H-imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1089283-49-7

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₄₄H₄₇F₂N₉O₅S

Molecular Weight: 851.96

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>100 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent IGF-1 R inhibitor

MDL Number: MFCD17010271

PubChem CID: 25124816

SMILES: CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F

InChi: InChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37 (59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49)

InChi Key: MOSKATHMXWSZTQ-UHFFFAOYSA-N