GSK2830371 | 2578

GSK2830371 is an allosteric Wip1 (Wild type p53-induced phosphatase) inhibitor (IC₅₀ of 6 nM). It binds to a flap subdomain that regulates Wip1's enzymatic activity and substrate recognition. Due to lack of this domain in other phosphatases, its binding to GSK2830371 results in a selective and potent inhibition of Wip1. Treatment of tumor cells with the inhibitor GSK2830371 increases phosphorylation of Wip1 substrates and causes growth inhibition in both hematopoietic tumor cell lines and Wip1-amplified breast tumor cells harboring wild-type TP53.

GSK2830371 is an allosteric Wip1 (Wild type p53-induced phosphatase) inhibitor (IC₅₀ of 6 nM). It binds to a flap subdomain that regulates Wip1's enzymatic activity and substrate recognition.

2578 | GSK2830371 DataSheet

Alternate Name/Synonyms: GSK-2830371

Appearance: Off-white to pale yellow solid

Formulation: N/A

CAS Number: 1404456-53-6

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₉CN₄O₂S

Molecular Weight: 461.02

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An allosteric Wip1 (Wild type p53-induced phosphatase) inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: CC1=C(NCC2=CC=C(C(N[C@@H](CC3CCCC3)C(NC4CC4)=O)=O)S2)C=C(Cl)C=N1

InChi: InChI=1S/C23H29ClN4O2S/c1-14-19(11-16(24)12-25-14)26-13-18-8-9-21(31-18)23(30)28-20(10-15-4-2-3-5-15)22(29)27-17-6-7-17/h8-9,11-12,15,17,20,26H,2-7,10,13H2,1H3,(H,27,29)(H,28,30)/t20-/m0/s1

InChi Key: IVDUVEGCMXCMSO-FQEVSTJZSA-N