Description
Cell-permeable. A potent inhibitor of cRAF1 kinase (IC₅₀ = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling.
GW-5074 is a potent inhibitor of cRAF1 kinase (IC₅₀ = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling.
Alternate Name/Synonyms: 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one
Appearance: Dark orange solid
Formulation: N/A
CAS Number: 220904-83-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₈Br₂INO₂
Molecular Weight: 520.95
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (~50 mg/ml)
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A c-RAF1 kinase inhibitor
MDL Number: MFCD03453076
PubChem CID: 5924208
SMILES: C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2
InChi: InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChi Key: LMXYVLFTZRPNRV-KMKOMSMNSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |