GW1100 | B2905

GW1100 is an antagonist for the free fatty acid receptor FFAR1 (GPR40). It inhibits GPR40-mediated Ca2+ elevations stimulated by GW 9508 (agonist for GPR40 and GPR120) and linoleic acid with pIC₅₀ values of 5.99 ± 0.03 and 5.99 ± 0.06 respectively. GW1100 reverses the potentiating effects of GW 9508 on glucose-stimulated insulin secretion in MIN6 mouse insulinoma cell line, at a concentration of 1 μM.

GW1100 is an antagonist for the free fatty acid receptor FFAR1 (GPR40). It inhibits GPR40-mediated Ca2+ elevations stimulated by GW 9508 (agonist for GPR40 and GPR120) and linoleic acid with pIC₅₀ values of 5.99 ± 0.03 and 5.99 ± 0.06 respectively. GW1100 reverses the potentiating effects of GW 9508 on glucose-stimulated insulin secretion in MIN6 mouse insulinoma cell line, at a concentration of 1 μM.

B2905 | GW1100 DataSheet

Alternate Name/Synonyms: Ethyl 4-[5-[(2-ethoxypyrimidin-5-yl)methyl]-2-[(4-fluorophenyl)methylsulfanyl]-4-oxopyrimidin-1-yl]benzoate; 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone; SB376752; Benzoic acid,4-[5-[(2-ethoxy-5-pyrimidinyl)methyl]-2-[[(4-fluorophenyl)methyl]thio]-4-oxo-1(4H)-pyrimidinyl]-,ethyl ester

Appearance: A crystalline solid

Formulation:

CAS Number: 306974-70-9

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₇H₂₅FN₄O₄S

Molecular Weight: 520.58

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~2 mg/ml in in DMSO, ~5 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antagonist for the free fatty acid receptor FFAR1 (GPR40)

MDL Number: MFCD09953714

PubChem CID: 11692123

SMILES: CCOC1=NC=C(C=N1)CC2=CN(C(=NC2=O)SCC3=CC=C(C=C3)F)C4=CC=C(C=C4)C(=O)OCC

InChi: InChI=1S/C27H25FN4O4S/c1-3-35-25(34)20-7-11-23(12-8-20)32-16-21(13-19-14-29-26(30-15-19)36-4-2)24(33)31-27(32)37-17-18-5-9-22(28)10-6-18/h5-12,14-16H,3-4,13,17H2,1-2H3

InChi Key: