GW2580 | 1740

A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro.

GW2580 is a small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases.

1740 | GW2580 DataSheet

Alternate Name/Synonyms: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 870483-87-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₂N₄O₃

Molecular Weight: 366.41

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A cFMS kinase inhibitor

MDL Number: N/A

PubChem CID: 11617559

SMILES: COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC

InChi: InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)

InChi Key: MYQAUKPBNJWPIE-UHFFFAOYSA-N