GYS1 (phospho-S641) Rabbit monoclonal Antibody | BS9838M

GYS1 (phospho-S641) Rabbit monoclonal Antibody | BS9838M | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC IHC

Application Range: WB: 1:1000-1:2000 ICC: 1:50-1:200 IHC: 1:50-1:200

Background: Glycogen [starch] synthase belongs to the mammalian/fungal glycogen synthase family of proteins. Two forms of this protein exist, a liver form and a muscle form, both of which have the same function in the glycogen biosynthesis pathway. Glycogen synthase transfers the glycosyl residue from UDP-Glucose to the nonreducing end of a-1,4-glucan. The liver glycogen synthase protein is truncated by 34 amino acids compared to the muscle form. However, these enzymes differ significantly in their amino- and carboxyl-terminal regions. Muscle glycogen synthase serves to fuel muscular activity only and is regulated by muscle contraction and by catecholamines. Liver glycogen synthase mediates blood glucose homeostasis in response to nutritional cues. Defects in the gene encoding liver glycogen synthase results in glycogen storage disease type 0 (GSD0), a rare form of fasting ketotic hypoglycemia.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of human GYS1 protein only when phosphorylated at Ser641.

Molecular Weight: ~ 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Glycogen [starch] synthase, muscle (EC:2.4.1.11) ; GYS1; GYS

Immunogen: Recombinant Antibody.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: Protein A affinity purified

Pathway: