H-RAS Antibody| F41616-0.08ML/F41616-0.4ML

H-RAS Antibody| F41616-0.08ML/F41616-0.4ML | Gentaur UK, US & Europe Distribution

Background: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: Rat, Chicken

Application: WB, IF, ELISA

Application Details: Western blot: 1:1000, Immunofluorescence: 1:10-1:50

Application Note: Titration of the H-RAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This H-RAS antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 146-176 from the human protein was used as the immunogen for this H-RAS antibody.

Storage: Aliquot the H-RAS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A