OG-L002 is a potent and specific inhibitor of Lysine Specific Demethylase-1(LSD-1) (IC₅₀ of 20 nM). Displays 36- and 69-fold selectivity over MAO-B and MAO-A, respectively. It potently represses...
L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is...