Hax1a Antibody [9F3D11] | PM-4718

Hax1a Antibody [9F3D11] | PM-4718 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Rat

Homology: N/A

Immunogen: Mouse monoclonal Hax1a antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human Hax1a.

Research Area: Apoptosis

Tested Application: E, WB

Application: Hax1a antibody can be used for detection of Hax1A by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Hax1a Monoclonal Antibody is Protein G purified.

Clonality: Monoclonal

Clone: 9F3D11

Isotype: IgG3

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Hax1a Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: Hax1a monoclonal antibody can be stored at -20˚C, stable for one year.

Alternate Name: Hax1a Antibody [9F3D11]: SCN3, HS1BP1, HCLSBP1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Hax1a Monoclonal Antibody: The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1) . Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr) , a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting. At least four isoforms of Hax1 are known to exist. This antibody is expected to recognize the longest isoform (Hax1a) as well as the shortest.