HB-EGF, human recombinant | 4266

HB-EGF is an EGF related growth factor which signals via the EGF receptor, and stimulates the proliferation of SMC (smooth muscle cells), fibroblasts, epithelial cells and keratinocytes. HB-EGF is expressed in various cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes and particular tumor cells. HB-EGF’s ability to explicitly bind heparin and heparin sulfate proteoglycans is dissimilar from other EGF-like molecules, and might be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells.

4266 | HB-EGF human recombinant DataSheet

Biomolecule/Target: HB-EGF

Synonyms: Proheparin-binding EGF-like growth factor, HBEGF, DTR, DTS, HEGFL, HB-EGF, Heparin-binding EGF-like growth factor, Diphtheria toxin receptor, DT-R, DTSF.

Alternates names: Leukocyte Elastase, ELA2

Taglines: EGF like growth factor involved in cell proliferation

NCBI Gene ID #: 1991

NCBI Gene Symbol: ELANE

Gene Source: Human

Accession #: P08246

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: 97%

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity:

Results:

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 29.5 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized with no additives

Reconstitution Instructions: Deionized HO

Amino acid sequence: N/A